How Tamiflu may help us.

Tamiflu: uses

Tamiflu is used to treat symptoms caused by flu virus ( influenza ) . It helps make the symptoms ( e. g. , stuffy nose, cough, sore throat, fever/chills, aches, tiredness ) less severe and shortens recovery time by 1-2 days. Tamiflu is also used to prevent flu if we have been exposed to someone who already has flu ( e. g. , sick household member ) .

Tamiflu works by stopping the flu virus from growing. It's not a substitute for flu vaccine. ( See Notes )

Tamiflu shouldn't be used in infants younger than 1 year of age. Consult your doctor or pharmacist for more details.

Tamiflu: how to use

Read Patient Information Leaflet available from your pharmacist before we start taking this medicine. If we have any questions, consult your doctor or pharmacist.

Take Tamiflu by mouth as directed by your doctor. You may take it with food or milk to minimize stomach upset. Take this medication as soon as flu symptoms appear or as soon as possible after we have been exposed to flu. Tamiflu works best if you start taking it within 2 days of either of these events.

If we have the flu, take Tamiflu usually twice a day for 5 days, or as directed by your doctor.

To prevent flu, take Tamiflu usually once a day for at least 10 days, or as directed by your doctor. Follow your doctor's instructions for how long to take this medicine.

Tamiflu works best when the amount of medicine in your body is kept at a constant level. Therefore, take Tamiflu at evenly spaced intervals at the same time ( s ) every day. Continue to take it for the full time prescribed. Stopping the medication too early may allow virus to continue to grow, which may result in a relapse of infection or failure to protect you from the flu.

Inform your doctor if your condition persists or worsens or if new symptoms appear.

Tamiflu: side effects

Nausea and vomiting may occur while use Tamiflu as your body adjusts to this medication and usually go away after 1-2 days. Dizziness may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed Tamiflu because he or she has judged that benefit to we is greater than risk of side effects. Many people using Tamiflu do not have serious side effects.

Tamiflu may rarely cause serious mental/mood changes. This may be more likely in children. Tell your doctor immediately of any signs of unusual behavior including confusion, agitation, self-injury.

Tell your doctor immediately if any of these rare but very serious side effects occur:

A very serious allergic reaction to Tamiflu is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include:

This isn't a complete list of possible side effects. If we notice other effects not listed above, contact your doctor or pharmacist.

Tamiflu: precautions

Before taking Tamiflu, tell your doctor or pharmacist if we are allergic to it; or if we have any other allergies.

Before using Tamiflu, tell your doctor or pharmacist your medical history, especially of:

Tamiflu may make we dizzy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages.

Tamiflu should be used only when clearly needed during pregnancy. Discuss risks and benefits with your doctor.

It's not known if Tamiflu passes into breast milk. Consult your doctor before breast-feeding.

Tamiflu: interactions

Your healthcare professionals ( e. g. , doctor or pharmacist ) may already be aware of any possible drug interactions and may be monitoring we for it. Don't start, stop, or change dosage of any medicine before checking with them first.

Before using Tamiflu, tell your doctor or pharmacist of all prescription and nonprescription/herbal products we may use especially of:

Tell your doctor if we have received flu vaccine in the nose within 2 weeks before treatment with Tamiflu. Tamiflu may lower your protection from flu vaccine given in the nose. Wait at least 2 days after ending treatment with Tamiflu before receiving flu vaccine given in the nose.

This document does not contain all possible interactions. Therefore, before using Tamiflu, tell your doctor or pharmacist of all products you use. Keep a list of all your medications with you, and share list with your doctor and pharmacist.

Shipping options for Tamiflu

Circulating Tumor Cells Are A Reliable Predictor Of Treatment Response In Metastatic Breast Cancer

With goal of tailoring cancer treatment for each individual, researchers at Georgetown University Medical Center have presented a study suggesting a simple blood test can help doctors more reliably assess treatment efficacy for patients with metastatic breast cancer.

" It can take several weeks and sometimes months to determine if a particular cancer treatment is working because it can take that long to observe any significant radiographic changes in tumor size or appearance, " says Minetta Liu, M. D. , of Georgetown's Lombardi Comprehensive Cancer Center. " Right now, we've to rely on radiology studies such as CT scans, ultrasound, and the like to determine whether or not there is disease progression. With this new blood test, we have another reliable tool that may allow us to determine much sooner if a therapy is ineffective so that we can change therapy earlier and potentially make more significant improvements in survival. "

Using the FDA-approved CellSearch™ technology, researchers measured number of circulating tumor cells ( CTC ) in blood collected from women with metastatic breast cancer. About one tablespoon of blood was collected every three to four weeks. The number of CTCs was correlated with disease response or progression as determined by standard radiology studies performed every 9-12 weeks. The women in study received various treatments including chemotherapy, endocrine therapy, and combination therapy with a biologic agent.

A CTC count of five was used as the threshold, based on previous studies. There was a highly significant difference in the distribution of progression between two groups of patients defined by their CTC result. Seventy-one percent of patients who had a CTC greater than or equal to five had disease progression, and 66 percent of patients with a CTC count of less than five did not.

" A CTC count of five or greater at time of restaging was associated with a 5. 32 fold increase in a patient's chance of having disease progression compared to CTC counts of less than five, " explains Liu. " CTC assessments should be used as a surrogate marker for treatment efficacy and disease responsiveness. Changes in CTC results from less than five to greater than or equal to five over time may herald disease progression. "

Liu adds that CTC assay is a more reliable means of assessing treatment response than the traditional tumor markers currently in use.

" We've a follow-up study underway that evaluates CTC results within the framework of a randomized clinical trial to eliminate potential variability from treatment administered, " says Liu, the national principal investigator of new trial. Liu and her colleagues believe a study with same therapies would offer even stronger evidence for routine use of CTC in patients with metastatic breast cancer.

" We've many treatment options for advanced breast cancer. The key is to find most effective therapy for each patient. It should not take months to figure that out, " she concludes.

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The study was funded by Veridex, LLC, makers of CellSearch. Liu reports receiving limited compensation for research-related speaking engagements on behalf of Veridex.

Liu's preliminary results have been released online in advance of American Society of Clinical Oncology annual meeting. The complete data will be presented during poster discussion of this study at the annual meeting place in Chicago May 30-June 3.

About Lombardi Comprehensive Cancer Center

The Lombardi Comprehensive Cancer Center, part of Georgetown University Medical Center and Georgetown University Hospital, seeks to improve diagnosis, treatment, and prevention of cancer through innovative basic and clinical research, patient care, community education and outreach, and training of cancer specialists of future. Lombardi is one of only 39 comprehensive cancer centers in the nation, as designated by National Cancer Institute, and only one in the Washington, DC, area. For more information, go to http: //lombardi. georgetown. edu/.

About Georgetown University Medical Center

Georgetown University Medical Center is an internationally recognized academic medical center with a three-part mission of research, teaching and patient care ( through our partnership with MedStar Health ) . Our mission is carried out with a strong emphasis on public service and a dedication to Catholic, Jesuit principle of cura personalis -- or " care of whole person. " The Medical Center includes School of Medicine and School of Nursing and Health Studies, both nationally ranked, world-renowned Lombardi Comprehensive Cancer Center and Biomedical Graduate Research Organization ( BGRO ) , home to 60 percent of the university's sponsored research funding.

Source: Karen Mallet Georgetown University Medical Center

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